Medische diagnostiek staat niet stil. Ook IBD plukt daar de vruchten van. Met klinische chemie kunnen medicijnspiegels in het bloed gemonitord worden, in de toekomst mogelijks zelfs via een simpele vingerprik. Andere mogelijke toekomstige innovatieve technieken zijn darmechografie voor diagnostiek & monitoring en camerapillen als vervanging van een endoscopie.
In deze podcast gaan de tafelgenoten in gesprek over mogelijke toekomstige innovatieve technieken.
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VERSIFY: intestinal ultrasonography & mucosal healing: Sands et al. Endoscopic, radiologic, and histologic healing with vedolizumab in patients with active Crohn’s disease. Gastroenterology. 2019 Oct;157(4):1007-1018.e7. doi: 10.1053/j.gastro.2019.06.038
TDM fingerprick tests: Kneepkens et al. Dried blood spots from finger prick facilitate therapeutic drug monitoring of adalimumab and anti-adalimumab in patients with inflammatory diseases. Br J Clin Pharmacol. 2017 Nov;83(11):2474-2484. doi: 10.1111/bcp.13371
Calpro tests at home: Young-Ho, 2018. Home-based fecal calprotectin test is expected to play an important role in patients with inflammatory bowel diseases. Intest Res. 2018 Oct; 16(4): 507–508
Videocapsule endoscopy: https://www.gastrojournal.org/article/S0016-5085(16)35560-3/fulltext
Parfenov et al. Role of video capsulе endoscopy in the diagnostic algorithm of small bowel Crohn’s disease. Ter Arkh. 2019 May 16;91(4):37-42. doi: 10.26442/00403660.2019.04.000079.
MRI: Barber et al. Early onset inflammatory bowel disease – What the radiologist needs to know. Clin Chim Acta. 2019 Aug;495:422-428. doi: 10.1016/j.cca.2019.05.003.
Judit Machnitz et al. MRI of the bowel – beyond inflammatory bowel disease. Pediatr Radiol. 2018 Aug;48(9):1280-1290. doi: 10.1007/s00247-018-4166-0
Serum albumin tests: Gonçalves-de-Albuquerque et al. Serum albumin saturation test based on non-esterified fatty acids imbalance for clinical employment. Clin Chim Acta. 2019 Aug;495:422-428. doi: 10.1016/j.cca.2019.05.003.
CRP test – pneumonia: Point-of-care CRP testing in the diagnosis of pneumonia in adults. Drug Ther Bull. 2016 Oct;54(10):117-120. doi: 10.1136/dtb.2016.10.0432.
Genomics – IBD SNPs: Momozawa et al. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nat Commun. 2018 Jun 21;9(1):2427. doi: 10.1038/s41467-018-04365-8.
Leukopenia – thiopurines gene tests: Shah et al, 2018. Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity. Drug Metab Pers Ther. 2018 Mar 28;33(1):57-60
Al-Judaibi et al, 2016. Genetic Predictors of Azathioprine Toxicity and Clinical Response in Patients with Inflammatory Bowel Disease. J Popul Ther Clin Pharmacol. 2016;23(1):e26-36
PANTS trial: Kennedy et al. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn’s disease: a prospective, multicentre, cohort study. Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3.
STRIDE paper: Peyrin-Biroulet et al. Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target. Am J Gastroenterol. 2015 Sep;110(9):1324-38
Rapid treatment escalation: Lee et al. Infliximab “Top-Down” Strategy is Superior to “Step-Up” in Maintaining Long-Term Remission in the Treatment of Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. 2015 Jun;60(6):737-43. doi: 10.1097/MPG.0000000000000711
Complications of corticosteroids: D’Haens. Systematic review: second-generation vs. conventional corticosteroids for induction of remission in ulcerative colitis. Aliment Pharmacol Ther. 2016 Nov;44(10):1018-1029. doi: 10.1111/apt.13803
Van den Brand et al. Adverse events related to low dose corticosteroids in autoimmune hepatitis. Aliment Pharmacol Ther. 2019 Oct 15. doi: 10.1111/apt.15528.
Multiomics: Weersma et al. Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease. Gastroenterology. 2018 Nov;155(5):e1-e4. doi: 10.1053/j.gastro.2018.07.039
